Failure of the Brain Glucagon-Like Peptide-1-Mediated Control of Intestinal Redox Homeostasis in a Rat Model of Sporadic Alzheimer’s Disease

The gastrointestinal system may be involved in the etiopathogenesis of insulin-resistant brain state (IRBS) and Alzheimer’s disease (AD). Gastrointestinal hormone glucagon-like peptide-1 (GLP-1) is being explored as a potential therapy activation GLP-1 receptors (GLP-1R) exerts neuroprotection controls peripheral metabolism. Intracerebroventricular administration streptozotocin (STZ-icv) used to model IRBS dyshomeostasis seems development neuropathological changes. aim was explore (i) homeostasis STZ-icv (ii) assess whether regulation redox (iii) analyze brain-gut axis functional animals. Acute intracerebroventricular treatment with exendin-3(9-39)amide for pharmacological inhibition GLP-1R control rats, oxidative stress assessed plasma, duodenum ileum. increased plasma stress. TBARS were increased, low molecular weight thiols (LMWT), protein sulfhydryls (SH), superoxide dismutase (SOD) decreased duodenum, but not ileum controls. In STZ-icv, CAT LMWT SH at baseline, no further increment observed upon central inhibition. presented results indicate that rat AD, signaling systemic regulation, regulates duodenal, ileal homeostasis, iv) dysfunctional model.